Schwannoma or neurilemmoma designate a tumour that originates in the Schwann cells of peripheral nerves, therefore occurring anywhere in the body. They are very rare in the penis. In the literature are reported twenty seven cases of penile schwannoma. We report a case of multiple schwannoma of the penis and make a brief literature revision about this rare pathology.

El schwanoma o neurilemoma es un tumor con origen en las células de Schwann de la vaina de los nervios periféricos. En la literatura están descritos veintisiete casos de schwanomas del pene. Presentamos un caso de schwanoma múltiple del pene, haciendo una breve revisión de la literatura sobre este raro tumor con respecto a su etiopatogenia, diagnóstico, tratamiento y orientación.

PURPOSE: We examined the significance of the CAG repeat polymorphism in the pathogenesis of cryptorchidism. MATERIALS AND METHODS: Genomic deoxyribonucleic acid (DNA) was extracted from blood samples from 42 cryptorchid boys and from 31 non-cryptorchid control subjects. In the cryptorchid group, 7 had bilateral cryptorchidism and 6 had patent processus vaginalis in the contralateral side. To determine the number of CAG repeats, the DNA was amplified by polymerase chain reaction and sequenced. RESULTS: The mean CAG repeat length in the AR gene was 22.5 (range 16 to 28) in patients and 21.5 (range 17 to 26) in controls (non-significant). Patients with bilateral cryptorchidism had a mean length of 24.3 (range 21 to 26) and patients with unilateral cryptorchidism and patent processus vaginalis in the contra lateral side had a mean of 25.2 (range 21 to 28), which was statistically different from controls (p = 0.015 and p = 0.005 respectively). CONCLUSION: CAG repeat length of the AR gene does not seem to play a major role in patients with unilateral cryptorchidism. However, in patients with bilateral undescended testis, a less functional androgen receptor through a longer polyglutamine chain may have a role in its pathogenesis. In the same way, patients with unilateral cryptorchidism a contralateral patent processus vaginalis have longer CAG repeats that might be responsible for a slower testicular descent and incomplete closure of the processus vaginalis.

INTRODUCTION: Bladder leiomyomas (BL) are rare. Most publications regarding these tumours are reports of isolated cases; therefore they don’t allow an evaluation of diagnostic and treatment procedures. MATERIAL & METHODS: We preformed a pooled analysis of 90 cases of BL reported in the literature.RESULTS: Mean age was 45.3 (19 to 85 years), 68 (75.6%) were women. Filling symptoms were the most frequently reported (50%), followed by voiding symptoms (24.4%). Twenty four patients (26.7%) were asymptomatic. Tumours were endoluminal in 46 patients (51.1%), intramural in 27 (30%) and extravesical in 15 (16.7%). A laparotomy was preformed in 56 patients (62.2%), with enucleation in 29 (32.2%), partial cystectomy in 25 (27.8%) and total cystectomy in 2 (2.2%). A transurethral resection was preformed in 27 (30%) and a transvaginal resection in 5 (5.6%). Two patients underwent conservative treatment. In 3 cases there were reports of recurrence and one patient got a vesicovaginal fistula. CONCLUSIONS: Although BL are rare, when evaluating bladder tumours, imaging techniques can make suspect of this neoplasm. Surgical treatment of these tumours has a very high success rate. Usually an enucleation or a transurethral resection is sufficient to render the patient tumour free, avoiding a more iatrogenic surgery.

INTRODUCCIÓN: Los leiomiomas de vejiga (LV) son tumores raros. La mayoría de las publicaciones relativas a estos tumores describen casos aislados, no permitiendo evaluar estrategias diagnósticas y terapéuticas. MATERIAL Y MÉTODO: Realizamos un análisis de agregación de 90 casos de LV descritos en la literatura internacional. RESULTADOS: La edad media al diagnóstico fue de 45,3 años (19-85 años), 68 (75,6%) eran mujeres. Los síntomas más frecuentes eran de almacenamiento (50%) seguidos de los de vaciado (24,4%). Veinticuatro pacientes (26,7%) estaban asintomáticos. Cuarenta y seis tumores (51,1%) tenían crecimiento endoluminal, 27 (30%) eran intramurales y 15 (16,7%) extravesicales. A 56 pacientes (62,2%) se les realizó una laparotomía, con enucleación en 29 (32,2%), cistectomía parcial en 25 (27,8%) y cistectomía total en 2 (2,2%). Veintisiete (30%) fueron sometidos a resección transuretral y 5 pacientes (5,6%) a una enucleación transvaginal. Dos pacientes no fueron sometidos a ningún tratamiento. Fueron descritas 3 recidivas y una fístula vesicovaginal como única complicación. CONCLUSIONES: Aunque el LV sea un tumor raro, en el estudio de una neoformación vesical, los estudios de imagen, pueden hacer sospechar este diagnóstico. El tratamiento quirúrgico tiene una alta tasa de éxito. En la mayoría de los casos, la resección transuretral o la enucleación es suficiente, evitando así una cirugía más iatrogénica.